Los Angeles Rams at San Francisco 49ers 4:25 p.m. EST

I think the Rams circled this game after losing in their first matchup. QB Matt Stafford has had several 25-plus point games, and he could easily do that again here with his weapons. WR Puka Nacua is back to practice after X-rays of his ribs were negative. He is a lock to score 20 points as long as he plays a complete game. They utilize him in numerous ways, and the volume is outstanding. WR Davante Adams is coming off back-to-back 20-plus point games, but his price tag is rising. While I love him as a player, he has a significant risk of busting at his price tag. He is going to be difficult for me to fit in with the better receivers on the slate. RB Kyren Williams scored over 30 points in his first meeting. I don’t think he will score 30, but I think he will score 20. He’s not my favorite back, but his consistency gets him in several of my lineups.
The 49ers got back on the winning track, and, shockingly, they have won as many games as they have. RB Christian McCaffrey is priced high, but I think we have to make lineups that can afford him. The Rams come with a ton of pressure, and the QB has to get the ball out quickly. We don’t know if that will be Brock Purdy or Mac Jones, but whoever it is will get CMC the football. We saw in the first matchup that the Rams could not cover him, and I don’t expect that to change. He is a lock for 20 points and could easily score 30 plus. I have some interest in WR Jauan Jennings, as he doesn’t have much competition, and his price remains relatively low. We are waiting for TE George Kittle to have a breakout game. I love his price, but he may be asked to block because of the pass rush. He will still make some lineups because he should automatically be priced higher.
Detroit Lions at Washington Commanders 4:25 p.m. EST

The Lions are coming off a big loss in which they barely eclipsed 300 yards in total offense. This should be a get-right game for them, and we can play everybody, including QB Jarred Goff. I love RB Jahmyr Gibbs and WR Amon-Ra St. Brown. Both could have monster games. TE Sam LaPorta is also worth playing along with WR Jameson Williams. I think the odd man out is RB David Montgomery, but I wouldn’t be shocked if he scores. I think we will need at least one player and possibly two to be in the winning lineups. Also, don’t be afraid of a blowout. The Lions have been known to run up the score, and they just might here, coming off a loss in which the offense struggled. They score 30-plus points.
The Commanders offense is banged up, and I don’t give them a chance. No QB Jayden Daniels, WR Terry McLaurin isn’t expected back, and even WR Luke McCaffrey was placed on IR. That leaves WR Deebo Samuel, who doesn’t look right, and aging TE Zach Ertz. Not very promising with QB Marcus Mariota. I think the Lions’ defense is the obvious play, and I wouldn’t be shocked if they were the top-scoring defense.
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