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Michael Wilson Week 16 Start and Sit
December 18, 2025 By  Fantasy NFL, Advice

Fantasy Football Start ‘Em Sit ‘Em Week 16

You know the feeling, but now it’s amplified. The safety net is gone. It’s the fantasy playoffs, and that glorious, maddening weekly riddle has morphed into a do-or-die ultimatum: WHO DO I START?

The stakes? No longer just a bad week – we’re talking season-ending, delete-the-app despair versus the intoxicating high of championship glory. You’re looking for that edge, that reassurance amidst the chaos.

Friends, I’m here for you. To give you my two cents on who needs to be touching grass to keep your title hopes alive and who needs to be riding pine before they pack your bags for you.

Week 16  Fantasy Football Start’Em Sit’Em

QUARTERBACKS

San Francisco 49ers quarterback Brock Purdy (13) scrambles out of the pocket against the Arizona Cardinals at State Farm Stadium in Glendale on Nov. 16, 2025. | Source: Lastwordonsports.com - Doug Henderson

Start: Joe Burrow (CIN @ MIA): I ain’t scurred. He still loves football, and we’ll see it this week. Vegas put this one in nuke territory, and Miami has been a top-10 friendly matchup for QBs on the season. If this turns into a shootout, Burrow’s volume and TD equity give you the kind of playoff-week ceiling that ends friendships.

Start: Brock Purdy (SF @ IND): The total is healthy, and Indy is more “middle-of-the-road” than “stay away” for QB scoring. If the 49ers offense is playing on schedule, Purdy can get there on efficiency and red-zone finishes alone.

Sit: Kirk Cousins (ATL @ ARI): Yes, the total is solid, but Arizona isn’t exactly a true QB ATM, and Cousins is the definition of fantasy “boom-or-bust” without legs. In the playoffs, you’re not paying for a quarterback whose good day depends on everything going perfectly clean and scripted.

Sit: Aaron Rodgers (PIT @ DET): Yes, he’s been serviceable, and yes, you may have just lost Patty Mahomes. So if you have to, I get it: Detroit games can get loud (49.5 total), and the Lions have been generous to QBs. But that’s exactly why this is a trap: the points come with chaos. If the plan breaks and it becomes a marathon, you’re looking at a fantasy playoffs faceplant.

About Doug Henderson

Doug Henderson grew up playing every sport imagineable. He quickly hit a ceiling his playing skills didn't let him break and had to turn to writing to get his sports fix.

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