New York Giants at Denver Broncos 4:05 p.m. EST

There is a lot of excitement in New York, and for good reason. QB Jaxon Dart and RB Cam Skattebo are energizing this team, but I think they will struggle in Denver. The Giants still have offensive line issues, and the Broncos can chase down running quarterbacks.
As for the Broncos, I love QB Bo Nix in this spot, along with WR Courtland Sutton. They could have big numbers against a porous Giants’ pass defense, and their prices won’t break the bank. I am expecting another receiver to break out. It could be Tony Franklin, but I feel Marvin Mims scores a long touchdown.
RB J.K. Dobbins should be solid, but he hasn’t scored more than 15.3 fantasy points all season, and you need your running backs to score 20 or more.
Indianapolis Colts at Los Angeles Chargers 4:05 p.m. EST

The Colts have my second-favorite play on the slate: running back Jonathan Taylor. The Chargers have been getting run over the last few weeks, and I expect this to happen again this week. I think he’s a lock for 20-plus points and possibly 30. QB Daniel Jones should be solid, but they must be playing from behind for him to put up big numbers. Tight end Tyler Warren is always a solid choice, but I think there are better tight end options. Figuring out the receivers has been challenging. I always prefer Michael Pittman, but Josh Downs can steal the show like last week.
I was right that RB Kimani Vidal would lead the Chargers’ running back group, but this week, he is priced up a bit in a tougher matchup. I think the passing game is where we have to look for the Chargers, but there is always a chance of failure because the Chargers’ offensive line is bad and could give up a bunch of sacks to the Colts. Still, I project QB Justin Herbert to break 20 points because he has been running a bit and has many weapons. Wide receiver Quintin Johnston is back practicing in full, but I still like WR Ladd McConkey. The Colts allow underneath passing, and he should be open as the Colts focus on Johnston from beating them deep. TE Oronde Gadsen is improving, but he has to score a TD because there are many solid tight ends on the slate.
Green Bay Packers at Arizona Cardinals 4:25 p.m. EST

The Packers can be a bit frustrating, but we know that RB Josh Jacobs and TE Tucker Kraft are solid plays and have been the most consistent players on the field. The receiving core is a bit mixed because we don’t know where all the volume is going. QB Jordan Love spreads the ball around, and the passing game outside of Kraft hasn’t been DFS viable.
For me, the Arizona offense all depends on who the quarterback is. If Kyler Murray is at the helm, I have no interest in the Cardinals. If Jacoby Brissett is the quarterback, then I think we have to look at TE Trey McBride as a big play. There is a good chance the Cardinals could be playing from behind, and he should see double-digit targets. WR Marvin Harrison junior has been limited in practice; he’s on concussion protocol. I think there’s a chance he could clear and be a good play on Sunday.