The Week 10 Colts vs Bills matchup features two NFL clubs moving in opposite directions. Buffalo (7-2), led by superstar quarterback Josh Allen, is one of the most complete and dangerous teams in football. The Bills have a stranglehold on the AFC East, leading the division by a whopping four games.
Meanwhile, Indianapolis (4-5) has experienced a roller-coaster season. Their former first-round quarterback, Anthony Richardson, was benched in favor of veteran Joe Flacco. Despite having playmakers like Jonathan Taylor, Michael Pittman, and Josh Downs, the Colts offense ranks in the bottom third of the league.
Star Josh Allen leads Buffalo into an advantageous matchup against Joe Flacco in this Colts vs Bills battle.
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Colts vs Bills Odds
- Moneyline: Bills (-210) vs Colts (+275)
- Spread: Bills -4.0 (-110) vs Colts +4.0 (-110)
- Over/Under: Over 47.5 (-110) / Under 47.5 (-110)
Colts vs Bills Prediction
IND Colts 17, BUF Bills 27
The Colts will attempt to get their dual threat offense centered around Flacco’s still dangerous arm and Jonathan Taylor’s top-tier rushing skills. Playing the middle-of-the-pack Bills passing defense should also allow weapons like Pittman to thrive. Unfortunately, the Colts lack the firepower to contend with Buffalo’s loaded roster.
Speaking of loaded, Allen and company cannot be underestimated. The Bills are riding a four-game win streak. They have yet to truly unleash new weapon Amari Cooper. Buffalo is a top four favorite to make the Super Bowl this season. Expect them to roll Indy by double-digits this week.
Colts vs Bills Best Bets
James Cook Anytime First Half Touchdown (+220)
Last season, Josh Allen was the ultimate touchdown vulture, rushing for an incredible 15 scores. This severly limited the number of touchdowns that Bills running back were able to accumulate.
Heading into Week 10, Allen only have three rushing scores this season. While he is still a dangerous goal line option, the Bills quarterback has yielded much more work to players like James Cook (who has already found the endzone seven times).
The Colts current have the second-worst defense in terms of rushing yards allowed, and have surrendered a league-high 15 rushing touchdowns. Cook is a serious threat to score two of more touchdowns (+400). However, more conservative bettors will want to take advantage of his first half scoring prop.
James Cook Over 63.5 Rushing Yards (-110)
Fortunately for Cook, Indy also has the second-worst defense in terms of rushing yards allowed (149.8). The game script, which should feature Buffalo getting out to an early and commanding lead, also lends itself to the Bills rushing the ball more than normally.
Cook is a real threat to surpass the 75 rushing yard (-160) and 100 rushing yard (+600) marks. Confidently bet the over on his 63.5 line!
Main Photo Courtesy of Gregory Fisher – Imagn Images
