Just one more week of non-conference play is all that stands between all the Big 12 members vying for a shot at winning the title. After three games, 25% of the season is already completed. The view of these teams is now colored in 2025 data and no longer pre-season expectations. Which brings us to our week two results, where we went 8-4 against the spread, 12-3 on Moneyline selections, and only 4-8 when picking the totals. With plenty of big numbers on the board, which of the Big 12 week three winners will surprise the public the most? All lines are courtesy of FanDuel.
Season Results
Moneyline: 27-4
Against The Spread: 14-11
Totals: 11-14
Locks: 2-0
Big 12 Week Three Winners
Colorado At Houston (-5.5)
The first of two games on a Friday night for the Big 12, this matchup in Houston brings plenty of intrigue. Colorado is expected to start third-string quarterback Ryan Staub. Houston has looked to be a team with a functional offense in 2025. Willie Fritz seems to have this program quickly moving in the right direction. Expect the Cougars to handle the Buffaloes.
Moneyline: Houston ATS: Houston Total 44.5: Under
Kansas State (-1.5) At Arizona
This is Kansas State’s last chance to save its season. They have, for some unknown reason, not turned quarterback Avery Johnson’s legs loose this season. In fact, he only has 78 rushing yards in three games. Arizona still hasn’t shown something significant to think they are a vastly improved squad under Brent Brennan in year two. A reminder that this game is considered a non-conference game, as this was a scheduling arrangement agreed upon before the Wildcats joined the Big 12. In the Wildcats’ battle, it is the visitors from Kansas who emerge victorious. But if they stumble and lose again, it’s fair to start worrying if they can even go to a bowl game.
Moneyline: Kansas State ATS: Kansas State Total 54.5: Over
Oregon State At #21 Texas Tech (-24.5)
Joey McGuire and company are looking to stay hot at home. They hope what they have seen over the last two weeks continues against a weak Pac-12 program. Another stifling performance pushes the Red Raiders to 3-0 heading into conference play.
Moneyline: Texas Tech ATS: Texas Tech Total 61.5: Under
Pitt At West Virginia (+7.5)
Last year, the Backyard Brawl got super wacky in a high-scoring affair. West Virginia struggled mightily in their loss to Ohio. Pitt has yet to be challenged so far in the season. But they have had plenty of offense to show for their two wins. Rich Rodriguez knows better than most what this game means. This will be the last matchup between these rivals until 2029. This is the must-watch game of the Big 12 week three winners we could pick from. In a perfect buy-low spot for the Mountaineers, they spring the upset in front of the home crowd.
Moneyline: West Virginia ATS: West Virginia Total 58.5: Over
#14 Iowa State (-20.5) At Arkansas State
No Big 12 school has a better resume to date than what Matt Campbell’s team has. This week, they make the trek into the Sun Belt conference. Arkansas State is coming off a 56-14 thumping by Arkansas. This will be nothing more than a chance for Rocco Becht to pad his stats to build on a Heisman campaign.
Moneyline: Iowa State ATS: Iowa State Total 55.5: Over
#20 Utah (-23.5) At Wyoming
Moneyline: Utah ATS: Utah Total 48.5: Under
Texas State At Arizona State (-14.5)
Moneyline: Arizona State ATS: Arizona State Total 58.5: Over
Main Photo: Ben Queen-Imagn Images
