Why should March get all the fun? There’s many reasons logisitically why a 64-team tournament for college football could not work. However, taking out the logistical challenges of this type of undertaking how entertaining would this be? Region by region, matchup by matchup we take you from 64 to one as we unveil our 2021 college football 64-team tournament.
First Round
West Region (64-team tournament)

| Source: Lastwordonsports.com - Jason Rhea (1) Alabama vs (16) Texas Tech 
| Source: Lastwordonsports.com - Jason Rhea


After giving up two early touchdowns to the Red Raiders, the number one overall seed dominates after the first quarter. The Tide advance easily by defeating Texas Tech 42-14.

| Source: Lastwordonsports.com - Jason Rhea (8) Minnesota vs (9) Auburn 
| Source: Lastwordonsports.com - Jason Rhea


Most fans were counting on an Iron Bowl rematch in the second round. However, Tanner Morgan shreds the Tiger secondary with four touchdowns as the Golden Gophers advance 35-27.

| Source: Lastwordonsports.com - Jason Rhea (4) Oregon vs (13) Arkansas 
| Source: Lastwordonsports.com - Jason Rhea


The Razorbacks continue to improve under Sam Pittman. But, their inexperience shows on the big stage and the Ducks win this matchup 42-20. Oregon runs for 450 yards in the victory.

| Source: Lastwordonsports.com - Jason Rhea (5) LSU vs (12) Tennessee 
| Source: Lastwordonsports.com - Jason Rhea


Josh Heupel has overachieved in his first season in Knoxville to get the Volunteers into the field of 64. Tennessee keeps it close for a half, but LSU wears them down for a 24-13 win.

| Source: Lastwordonsports.com - Jason Rhea (3) Cincinnati vs (14) Mississippi State 
| Source: Lastwordonsports.com - Jason Rhea


Finally, we have our first huge upset of the 2021 College Football tournament. The loss of defensive coordinator Marcus Freeman is felt here as Mike Leach and company outscore Cincinnati 45-41.

| Source: Lastwordonsports.com - Jason Rhea (6) Penn State vs (11) Stanford 
| Source: Lastwordonsports.com - Jason Rhea


Both Penn State and Stanford struggled in a crazy 2020 season. However, the Nittany Lions played better toward the end of the season. They take that momentum through a first-round win, 27-21.

| Source: Lastwordonsports.com - Jason Rhea (2) Iowa State vs (15) SMU 
| Source: Lastwordonsports.com - Jason Rhea


The Cyclones had their best season in school history in 2021. They capitalize off of that for a dominating 45-14 win over SMU.

| Source: Lastwordonsports.com - Jason Rhea (7) Arizona State vs (10) Kentucky 
| Source: Lastwordonsports.com - Jason Rhea


We have our second upset in the West region in this 7/10 matchup. The Wildcats defense slows down the high-powered Sun Devil offense in a 17-13 triumph.
East Region (64-team tournament)

| Source: Lastwordonsports.com - Jason Rhea (1) Clemson vs (16) West Virginia 
| Source: Lastwordonsports.com - Jason Rhea


The Tigers narrowly dodge the dreaded 16 seeded upset as they rally for the 38-35 win over the Mountaineers after a late turnover opened the door for Clemson to escape.

| Source: Lastwordonsports.com - Jason Rhea (8) Utah vs (9) TCU 
| Source: Lastwordonsports.com - Jason Rhea


TCU didn’t see the improvement that they expected in 2021. However, it all comes together for the Horned Frogs as they score the minor upset over Utah.

| Source: Lastwordonsports.com - Jason Rhea (4) Washington vs (13) Virginia Tech 
| Source: Lastwordonsports.com - Jason Rhea


The Hokies enter the tournament with Justin Fuente needing a victory to save his job. And, they do just that in wrecking the Washington postseason for the second year in a row.

| Source: Lastwordonsports.com - Jason Rhea (5) Ole Miss vs (12) Kansas State 
| Source: Lastwordonsports.com - Jason Rhea


The Rebels are rolling in the second year under Lane Kiffin. Even though Kansas State has been a giant killer in the Big 12, that doesn’t happen today as the Rebels roll.

| Source: Lastwordonsports.com - Jason Rhea (3) Indiana vs (14) BYU 
| Source: Lastwordonsports.com - Jason Rhea


The Hoosiers are one of the best teams in the Big 10 and they roll past the Cougars. Conversely, BYU had a season of struggles trying to replace Zack Wilson at quarterback.

| Source: Lastwordonsports.com - Jason Rhea (6) Coastal Carolina vs (11) Boise State 
| Source: Lastwordonsports.com - Jason Rhea


Speaking of quarterbacks, one of the best dual-threats in the country Grayson McCall lead the Chanticleers to a thrilling victory in an instant classic over Boise State.

| Source: Lastwordonsports.com - Jason Rhea (2) Texas A&M vs (15) San Jose State 
| Source: Lastwordonsports.com - Jason Rhea


Texas A&M rolls into the tournament as one of the top teams in the country. They show exactly why as they steamroll San Jose State in the first round.

| Source: Lastwordonsports.com - Jason Rhea (7) Miami vs (10) UCLA 
| Source: Lastwordonsports.com - Jason Rhea


This is a matchup of two outstanding quarterbacks in D’Eriq King and Dorian Thompson-Robinson. King gets the edge as the Hurricanes advance to the next round.
South Region (64-team tournament)

| Source: Lastwordonsports.com - Jason Rhea (1) Georgia vs (16) Florida State 
| Source: Lastwordonsports.com - Jason Rhea


JT Daniels capitalizes on the Heisman finalist season in Athens as the Bulldogs throttle the Seminoles in their opening-round matchup.

| Source: Lastwordonsports.com - Jason Rhea (8) Northwestern vs (9) Missouri 
| Source: Lastwordonsports.com - Jason Rhea


Pat Fitzgerald‘s club was much improved in 2020. But, Missouri can also lay that claim. The Wildcats win a close 24-21 decision.

| Source: Lastwordonsports.com - Jason Rhea (4) Notre Dame vs (13) Nebraska 
| Source: Lastwordonsports.com - Jason Rhea


The biggest blue-blood matchup of the first round occurs here with Notre Dame facing off against Nebraska. However, the Irish dominate in what could spell the end of the Scott Frost tenure in Lincoln.

| Source: Lastwordonsports.com - Jason Rhea (5) Wisconsin vs (12) California 
| Source: Lastwordonsports.com - Jason Rhea


The Badgers return to more consistency in 2021 and that shows as they win convincingly over the Golden Bears.

| Source: Lastwordonsports.com - Jason Rhea (3) USC vs (14) Nevada 
| Source: Lastwordonsports.com - Jason Rhea


PAC 12 Offensive Player of the Year Kedon Slovis shines as USC wins the opener in a comfortable fashion.

| Source: Lastwordonsports.com - Jason Rhea (6) Texas vs (11) Purdue 
| Source: Lastwordonsports.com - Jason Rhea


The Longhorns were up and down in Steve Sarkisian‘s first year in Austin. But, they do enough to get a first round victory over the Boilermakers.

| Source: Lastwordonsports.com - Jason Rhea (2) Ohio State vs (15) South Carolina 
| Source: Lastwordonsports.com - Jason Rhea


It’s evident that Shane Beamer needs time to right the ship in Carolina. The Buckeyes cruise.

| Source: Lastwordonsports.com - Jason Rhea (7) Oklahoma State vs (10) Memphis 
| Source: Lastwordonsports.com - Jason Rhea


Memphis took a step back on offense with Brady White moving on and they can’t outscore the Cowboys in this one.
Midwest Region (64-team tournament)

| Source: Lastwordonsports.com - Jason Rhea (1) Oklahoma vs (16) San Diego State 
| Source: Lastwordonsports.com - Jason Rhea


The Sooners struggle early on in this one, but find their groove in the second half for a convincing victory.

| Source: Lastwordonsports.com - Jason Rhea (8) Army vs (9) NC State 
| Source: Lastwordonsports.com - Jason Rhea


The Cadets enjoyed yet another tremendous season and complete that with a win over the Wolfpack.

| Source: Lastwordonsports.com - Jason Rhea (4) Florida vs (13) Colorado 
| Source: Lastwordonsports.com - Jason Rhea


The Gators weren’t quite as explosive on offense in 2021, but have enough to take care of the Buffaloes.

| Source: Lastwordonsports.com - Jason Rhea (5) Louisiana vs (12) Boston College 
| Source: Lastwordonsports.com - Jason Rhea


Louisiana obtained a high-seed due to their double-digit win total. They continue their success with a tight win over Boston College.

| Source: Lastwordonsports.com - Jason Rhea (3) Iowa vs (14) Appalachian State 
| Source: Lastwordonsports.com - Jason Rhea


This was the biggest upset prediction of the first round. But, it was not to be as the Hawkeyes controlled from the opening kick.

| Source: Lastwordonsports.com - Jason Rhea (6) Liberty vs (11) UCF 
| Source: Lastwordonsports.com - Jason Rhea


This was perhaps the best Quarterback matchup of the first round. In a minor upset, Dillon Gabriel outduels Malik Willis.

| Source: Lastwordonsports.com - Jason Rhea (2) North Carolina vs (15) Michigan State
| Source: Lastwordonsports.com - Jason Rhea


Sam Howell shows why he was arguably the best quarterback in the country in 2021. He throws five touchdowns in the opening round romp.

| Source: Lastwordonsports.com - Jason Rhea (7) Michigan vs (10) Pittsburgh 
| Source: Lastwordonsports.com - Jason Rhea


In our final game of the first round, we have a much improved Michigan team winning on a last minute field goal to advance.
Round of 32
West Region (64-team tournament)

| Source: Lastwordonsports.com - Jason Rhea (1) Alabama vs (8) Minnesota 
| Source: Lastwordonsports.com - Jason Rhea


The Crimson Tide’s running game and defense too much as Alabama cruises into the Sweet 16.

| Source: Lastwordonsports.com - Jason Rhea (4) Oregon vs (5) LSU 
| Source: Lastwordonsports.com - Jason Rhea


LSU jumps out to a 17-point halftime lead. But, the Ducks come roaring back off of a late Tiger turnover to complete the improbable comeback.

| Source: Lastwordonsports.com - Jason Rhea (6) Penn State vs (14) Mississippi State 
| Source: Lastwordonsports.com - Jason Rhea


Nittany Lions defense is able to slow down Leach’s passing game with a 10-point win.

| Source: Lastwordonsports.com - Jason Rhea (2) Iowa State vs (10) Kentucky 
| Source: Lastwordonsports.com - Jason Rhea


Breece Hall runs for 185 yards as the Cyclones win comfortably to make it to the Sweet 16.
East Region (64-team tournament)

| Source: Lastwordonsports.com - Jason Rhea (1) Clemson vs (9) TCU 
| Source: Lastwordonsports.com - Jason Rhea


TCU learns early on that the Clemson offense is on a different level as the Tigers cruise to a 24-point victory.

| Source: Lastwordonsports.com - Jason Rhea (5) Ole Miss vs (13) Virginia Tech 
| Source: Lastwordonsports.com - Jason Rhea


The Cinderella slippers no longer fit as the Kiffin’s club gets to the Sweet 16.

| Source: Lastwordonsports.com - Jason Rhea (3) Indiana vs (6) Coastal Carolina 
| Source: Lastwordonsports.com - Jason Rhea


The Hoosiers follow up one of the best seasons in 2020 with an equally strong one this year. They outduel Carolina, 41-38.

| Source: Lastwordonsports.com - Jason Rhea (2) Texas A&M vs (7) Miami 
| Source: Lastwordonsports.com - Jason Rhea


The Hurricanes secure the biggest upset of the second round. King makes the most of his decision to come back with a monumental win.
South Region (64-team tournament)

| Source: Lastwordonsports.com - Jason Rhea (1) Georgia vs (8) Northwestern 
| Source: Lastwordonsports.com - Jason Rhea


The Bulldogs show they are ready for the post season as they dominate the Wildcats, 42-10.

| Source: Lastwordonsports.com - Jason Rhea (4) Notre Dame vs (5) Wisconsin 
| Source: Lastwordonsports.com - Jason Rhea


A rematch of a regular season matchup won by Wisconsin. However, the Fighting Irish get the better part of the rematch.

| Source: Lastwordonsports.com - Jason Rhea (3) USC vs (6) Texas 
| Source: Lastwordonsports.com - Jason Rhea


Plenty of storylines here in one of the most appealing second-round matchups. The Longhorns get a goalline stand to come away with the upset victory.

| Source: Lastwordonsports.com - Jason Rhea (2) Ohio State vs (7) Oklahoma State 
| Source: Lastwordonsports.com - Jason Rhea


The Cowboy defense struggles in this one as Master Teague runs for over 200 yards and the Buckeyes win comfortably.
Midwest Region (64-team tournament)

| Source: Lastwordonsports.com - Jason Rhea (1) Oklahoma vs (8) Army 
| Source: Lastwordonsports.com - Jason Rhea


The Sooners struggled a few years ago in a near monumental upset for Army. But, Oklahoma is more equipped defensively this time for a 31-10 victory.

| Source: Lastwordonsports.com - Jason Rhea (4) Florida vs (5) Louisiana 
| Source: Lastwordonsports.com - Jason Rhea


Louisiana gives the Gators everything they want. However, the depth in the trenches proves too much as Florida advances.

| Source: Lastwordonsports.com - Jason Rhea (3) Iowa vs (11) UCF 
| Source: Lastwordonsports.com - Jason Rhea


UCF becomes just the first double-digit seed to advance. Gabriel leads the Knights once again.

| Source: Lastwordonsports.com - Jason Rhea (2) North Carolina vs (7) Michigan 
| Source: Lastwordonsports.com - Jason Rhea


Carolina completes our Sweet 16 field as they complete a workmanlike effort over the Wolverines.
Sweet 16
West Region (64-team tournament)

| Source: Lastwordonsports.com - Jason Rhea (1) Alabama vs (4) Oregon 
| Source: Lastwordonsports.com - Jason Rhea


The Crimson Tide put together their most complete game of the tournament with a 34-17 victory over the Ducks.

| Source: Lastwordonsports.com - Jason Rhea (2) Iowa State vs (6) Penn State 
| Source: Lastwordonsports.com - Jason Rhea


It’s the Cyclones and not the blue-blooded Nittany Lions that flex their muscles as Iowa State makes it to the Elite Eight.
East Region (64-team tournament)

| Source: Lastwordonsports.com - Jason Rhea (1) Clemson vs (5) Ole Miss 
| Source: Lastwordonsports.com - Jason Rhea


Tiger quarterback DJ Uiagalelei continues to stay hot as the Tigers blitz Ole Miss 41-13.

| Source: Lastwordonsports.com - Jason Rhea (3) Indiana vs (7) Miami 
| Source: Lastwordonsports.com - Jason Rhea


The dream postseason for the Hurricanes continue as they get another upset victory to head to the Elite Eight.
South Region (64-team tournament)

| Source: Lastwordonsports.com - Jason Rhea (1) Georgia vs (4) Notre Dame 
| Source: Lastwordonsports.com - Jason Rhea


Notre Dame was out to prove that they could compete at the national level with a perenial giant. However, while the Irish make it more competitive Georgia comes out with the win.

| Source: Lastwordonsports.com - Jason Rhea (2) Ohio State vs (6) Texas 
| Source: Lastwordonsports.com - Jason Rhea


The Longhorns overachieved in this tournament compared to their regular season. That comes to an end as the Buckeyes handle their business with a 31-24 win.
Midwest Region (64-team tournament)

| Source: Lastwordonsports.com - Jason Rhea (1) Oklahoma vs (4) Florida 
| Source: Lastwordonsports.com - Jason Rhea


The Sooners have the opportunity to exact some revenge against Florida in the playoffs. And, Oklahoma did just that in a 34-21 victory.

| Source: Lastwordonsports.com - Jason Rhea (2) North Carolina vs (11) UCF 
| Source: Lastwordonsports.com - Jason Rhea


The magic continues for UCF as they pull another massive upset against the Tar Heels this time.
Elite Eight
West Region

| Source: Lastwordonsports.com - Jason Rhea (1) Alabama vs (2) Iowa State 
| Source: Lastwordonsports.com - Jason Rhea


The Cyclones pride themselves on being one of the few FBS teams to not get blown out. That trend continues here, but Iowa State doesn’t have enough as Alabama punches its ticket to the Final Four.
East Region

| Source: Lastwordonsports.com - Jason Rhea (1) Clemson vs (7) Miami 
| Source: Lastwordonsports.com - Jason Rhea


Clemson and Miami are two teams that are very familiar with each other. The Tigers have dominated each of the matchups against the Hurricanes. Nothing changes here as the Tigers win 49-21.
South Region

| Source: Lastwordonsports.com - Jason Rhea (1) Georgia vs (2) Ohio State 
| Source: Lastwordonsports.com - Jason Rhea


Two historic programs collide in a game which is disappointing to see either team lose. But, the inexperience in a big game for the Buckeyes at the quarterback position comes back to bite them as the Bulldogs advance to the Final Four.
Midwest Region

| Source: Lastwordonsports.com - Jason Rhea (1) Oklahoma vs (11) UCF 
| Source: Lastwordonsports.com - Jason Rhea


An unexpected matchup here as the Sooners lock up with the Knights. After a back and forth first half, the Sooners take control of the second half to advance.
Final Four

| Source: Lastwordonsports.com - Jason Rhea (1) Alabama vs (1) Clemson 
| Source: Lastwordonsports.com - Jason Rhea


We knew that we would get this matchup at some point. Two of most dominant programs in the sport lock up once again. This time, Clemson gets the advantage in another class in a 28-24 win.

| Source: Lastwordonsports.com - Jason Rhea (1) Georgia vs (1) Oklahoma 
| Source: Lastwordonsports.com - Jason Rhea


The Sooners return to the Final Four against a familiar opponent. The opportunity for revenge in one of the most dissapointing losses in Oklahoma football history was seized by the Sooners in a 31-28 win.
National Championship

| Source: Lastwordonsports.com - Jason Rhea (1) Clemson vs (1) Oklahoma
| Source: Lastwordonsports.com - Jason Rhea


Clemson is back in familiar territory playing for a national championship. Comparatively, Oklahoma finally got over the hump and got their first win in the Final Four over Georgia. The offensive line for the Tigers and overall defensive performance for the Sooners which have been in question for both programs over the last few years have become a strength for both teams. However, the great offense for both teams are on display. But, Oklahoma will get the last laugh as Spencer Rattler throws a game-winning touchdown pass with 27 seconds remaining to give Oklahoma their eighth national championship in program history.